Scientists decipher why smokers find it difficult to quit smoking

Escape from what is called a poison called tobacco - is not an easy task. For some it takes years, while others seem unable to leave.

Previous studies have shown that smoking addiction is real. But why is it so hard to give up? University of Michigan scientists have found the answer.

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Researchers have confirmed that a genetic mechanism has been disturbed by nicotine dependence as well as pulmonary withdrawal effects making it extremely difficult to give up smoking.

According to this study, it was discovered that a specific gene and microRNA (a small RNA molecule that modulates good gene expression) play an essential role in determining the dependence and response to nicotine withdrawal.

The researchers examined detoxification reactions in the nematode Caenorhabditis elegans (C. elegans) and those related to nicotine withdrawal like humans.

They discovered a series of genes in the roundworm that are involved in increasing the production of nicotine receptor proteins, with microRNAs playing an important role.

"We are seeing a clear link between nicotine, microRNA, receptor proteins, and nicotine-dependent behavior," said lead author Jianke Gong.

The results published in Cell Reports show that C. elegans' latest reaction will help other scientists re-examine the role of RNAs in nicotine dependence in mammals and eventually leading to a better understanding of the cause of this toxic nicotine dependence.