Troubleshooting audio problems on your Mac isn't always easy. macOS lacks a comprehensive set of tools to diagnose and fix problems. Therefore, you must use your own judgment to find the source of the problem. Hopefully some of the methods mentioned above can help you fix the error of speakers losing sound on Macbook effectively. If you use Win 10 and encounter the same situation, please refer to How to fix sound loss error in Windows 10 here.