NVIDIA GeForce RTX 30 Series or higher
Graphics AMD Radeon RX 5000 Series or higher
NVIDIA GeForce RTX 20 Series or higher
Graphics AMD Radeon RX 5000 Series or higher
NVIDIA GeForce RTX 20 Series or higher
Supported
Graphics AMD Radeon RX 5000 Series or higher
NVIDIA GeForce RTX 20 Series or higher
Graphics AMD Radeon RX 500 Series or higher
NVIDIA GeForce GTX 10 Series or higher
Graphics AMD Radeon RX 500 Series or higher
NVIDIA GeForce GTX 10 Series or higher
Additionally, while FSR 3 and 2 are optimized to work with dedicated graphics cards, they can still be used with some Ryzen processors that come with AMD's integrated Radeon graphics.
Using FSR is simply a matter of enabling the setting in whatever game you're playing. Keep in mind that the game needs to support FSR for you to use this tool, so it won't be available in every game.
Luckily, the list of supported games is quite long, with over 100 games supported on FSR versions. You can check out the FSR supported games page on AMD's website for details. New games are constantly being added to the list, so there's a good chance the game you want to play will be supported.
In cases where a game doesn't support AMD FSR, you can still use something called Radeon Super Resolution or RSR to upscale almost any game you want. This technology is based on FSR 1 and can work in any full-screen proprietary game without the game developer having to add any additional software support. The only downside is that you need at least an AMD 5000 series GPU to run it, as this feature is part of AMD graphics drivers and can only run on AMD GPUs.
FSR won't magically make every game better, however, as the PC hardware still has to do all the heavy lifting. When I tried playing Hellblade 2, my test laptop struggled to get past 20FPS even with the graphics settings turned down to the lowest possible setting and FSR running at full throttle.
Different games also react differently to FSR's intervention, meaning your performance will vary. For example, while Forza Horizon 5 and Warframe run well above 60 FPS with respectable graphics, Warzone and Ghost of Tsushima are a bit too much, with random bugs popping up.