Science successfully created 3D lung models with the size and characteristics of true lungs

A small 3D lung structure (organoid) has been successfully developed, capable of mimicking the full characteristics of the lungs allowing scientists to study and experiment in a laboratory environment.

Specifically, researchers at Columbia University Medical Center (CUMC) created an organoid (which is a scaled-down and simplified version of an in vitro organ produced in 3D space that helps for more precise surgery and research) of the lungs to mimic lung characteristics, full size to learn and study respiratory diseases better.

They created an organoid-like 3D structure made of human pluripotent stem cells, creating lung and respiratory disease models for new experiments in the future.

Organoid created at CUMC contains branched airways and alveolar structures such as those in human lungs.

Science successfully created 3D lung models with the size and characteristics of true lungs Picture 1

Organoid contains many types of cells and specific functions such as in a complete lung, which will allow researchers to try new drugs as well as experiments related to regenerating damaged tissue.

Hans-Willem Snoeck, CUMC medical professor said: " These organs are produced by embryonic stem cells with the potential of many embryonic stem cells and modified stem cells from the The gene, this is one of the best prerequisites for studying respiratory-related diseases, 'he said in a press release.

The researchers showed that this lung organoid reacted in a real lung when infected with respiratory syncytial virus or RSV and other experiments showed that organoid also reacted like human lungs when caused by a gene mutation. Pulmonary fibrosis disease.

" Researchers have come up with more challenges in creating chlorine in the lungs to understand, prevent, and treat lung-related diseases. And our ability to do it has been, " Snoeck said . creating regenerative internal organs similar to the characteristics and symptoms of respiratory diseases in humans '.

This research has just been published in the journal Nature Cell Biology.