In March 2024, investigators discovered that dairy cows in the United States had been infected with H5N1. For those who study the disease, it was a wake-up call. Avian influenza is rare in cows and has never infected an entire herd. 'Every once in a while, a cow gets infected, but they're not a natural host for influenza A viruses, so this really shocked the field, ' says immunologist Jenna Guthmiller of the University of Colorado.
The virus has since spread to more than 700 cattle herds in the United States. Several farms in California and Colorado have been quarantined, and some states are requiring testing of cows purchased from out of state.
Cows are much larger than birds and shed more biological material that could carry H5N1. The process of bringing them into warehouse-like facilities and milking them with mechanical equipment is raising concerns that infectious waste could spread rapidly through the herd.